Preparation of substituted alkoxypyridines via directed metalation and metal-halogen exchange

Preparation of substituted alkoxypyridines via directed metalation and metal-halogen exchange

Several halo-substituted alkoxypyridines were prepared and subjected to directed metalation and metal-halogen exchange reactions. The studies resulted in useful methods for synthesis of numerous substituted pyridines via regioselective lithiation, magnesation and halogen dance reactions. [GRAPHICS]

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Veröffentlicht in:ARKIVOC free online journal of organic chemistry 2021-02, Vol.2021 (5), p.57-72
Hauptverfasser: Bori, Ibrahim D., Comins, Daniel L.
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
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Zusammenfassung:Several halo-substituted alkoxypyridines were prepared and subjected to directed metalation and metal-halogen exchange reactions. The studies resulted in useful methods for synthesis of numerous substituted pyridines via regioselective lithiation, magnesation and halogen dance reactions. [GRAPHICS]
ISSN:1551-7004
1551-7012
1551-7012
DOI:10.24820/ark.5550190.p011.464