Assessment of role of rosmarinic acid in preventing oxidative process of low density lipoproteins
This study aimed to assess the antioxidant compound effects on oxidisable substrates, using an effective bio-mimetic system based on human low density lipoproteins (LDL). Thermally generated radicals induce LDL oxidative changes to be identified and quantified. The bio-mimetic system thus developed...
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Veröffentlicht in: | Chemical papers 2012-12, Vol.66 (12), p.1166-1170 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | This study aimed to assess the antioxidant compound effects on oxidisable substrates, using an effective bio-mimetic system based on human low density lipoproteins (LDL). Thermally generated radicals induce LDL oxidative changes to be identified and quantified. The bio-mimetic system thus developed responded linearly to radicals’ concentration over a range of 10
−6
-10
−5
mol L
−1
. Cu
2+
accentuates lipoperoxidation but, when rosmarinic acid was present, Cu
2+
produced an unexpected effect, i.e. increased antioxidant efficiency against lipoperoxidation. Rosmarinic acid inhibits production of lipoperoxides by up to 30 % in the absence of Cu
2+
and up to 70 % in its presence when the rosmarinic acid-to-Cu molar ratio is 1: 1. |
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ISSN: | 0366-6352 1336-9075 1336-9075 |
DOI: | 10.2478/s11696-012-0233-4 |