PROGNOSTIC CLINICAL, MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL MARKERS OF LOW-GRADE SEROUS OVARIAN CARCINOMAS OF WOMEN WITH SEROUS BORDERLINE TUMORS IN ANAMNESIS

The problem of finding reliable clinical and morphological criteria for diagnosis and prognosis of serous borderline ovarian tumors, their relationship with the risk of developing of low-grade serous ovarian carcinomas (LGSC) in future is still relevant. This study is devoted to research and highlig...

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Veröffentlicht in:Periodyk Naukowy Akademii Polonijnej 2022-01, Vol.48 (5), p.165-172
1. Verfasser: Hryhorenko, Varvara
Format: Artikel
Sprache:eng
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Zusammenfassung:The problem of finding reliable clinical and morphological criteria for diagnosis and prognosis of serous borderline ovarian tumors, their relationship with the risk of developing of low-grade serous ovarian carcinomas (LGSC) in future is still relevant. This study is devoted to research and highlight of precursors that allow dividing women with serous borderline ovarian tumors (SBOT) into risk group for occurrence of LGSC within next 5 years. The study included 22 patients with FIGO stage I-II SBOT aged 24 to 46 years, 9 (39.13%) of whom were diagnosed with high-grade serous ovarian carcinoma next 5 years. Two study groups were formed: the control group (n = 13), which included patients with SBOT without further development of LGSC, and the main group (n = 9), which included women with emerging LGSCs. We studied expression of immunohistochemical markers Ki-67, MMP-9, p53, Bcl-2, E-cadherin, and also a diameter and localization of the tumor. As a result of the study, it was found that patients with diameter of the SBOT≥10 cm (χ² = 6.0, p
ISSN:1895-9911
2543-8204
DOI:10.23856/4821