A Case of Multiple Endocrine Neoplasia Type 1 During Long-term Follow-up

The case was a 54-year-old male patient. He had a medical history of gastric ulcer. At the age of 42, he was performed partial resection of the jejunum due to perforation of multiple jejunal ulcers. After the initial surgery, he was again diagnosed with gastrointestinal perforations. Zollinger-Ellison Syndrome was strongly suspected and pancreaticoduodenectomy was performed. Histological examination of the resected specimen revealed multiple duodenal submucosal gastrinomas and non-functioning pancreatic neuroendocrine tumors. He visited a neighboring hospital because of a back pain in April 2011. Computed tomography（CT）and fluorine-18 deoxyglucose positron emission tomography（FDG-PET）revealed a tumor in the tail of the pancreas measuring 39×27mm in diameter, and suspected a malignant tumor. Distal pancreatectomy and splenectomy was performed in July 2011. The final pathological diagnosis was non-functional pancreatic neuroendocrine tumor. We performed genetic testing on him and mutation of the MEN1 gene was identified．The patient was therefore diagnosed as multiple endocrine neoplasia type 1. No recurrence was noted within the 6 years since undergoing the operation. We experienced a case of multiple endocrine neoplasia type 1 during long-term follow-up and report this case with some literature reviews.