Oral Antihyperglycemic Medication Nonadherence and Subsequent Hospitalization Among Individuals With Type 2 Diabetes

Oral Antihyperglycemic Medication Nonadherence and Subsequent Hospitalization Among Individuals With Type 2 Diabetes Denys T. Lau , PHD 1 and David P. Nau , PHD 2 1 Pfizer Research Fellowship Program, Department of Health Management and Policy, The University of Michigan School of Public Health, Ann Arbor, Michigan 2 Department of Social and Administrative Sciences, The University of Michigan College of Pharmacy, Ann Arbor, Michigan Address correspondence and reprint requests to David P. Nau, PhD, Assistant Professor, Department of Social and Administrative Sciences, The University of Michigan College of Pharmacy, 428 Church St., Ann Arbor, Michigan 48109-1065. E-mail: dnau{at}umich.edu Abstract OBJECTIVE —This study examines the association between oral antihyperglycemic medication nonadherence and subsequent hospitalization among individuals with type 2 diabetes. RESEARCH DESIGN AND METHODS —Using administrative claims data (2000–2001) from a managed care organization in the Midwestern U.S., this study analyzed 900 enrollees, aged 18 years and over, with type 2 diabetes who were taking oral antihyperglycemic agents both years but who did not use insulin. Nonadherence was defined as a medication possession ratio (MPR)