Assessment of Aortic Pulse Wave Velocity and Cardiac Diastolic Function in Subjects With and Without the Metabolic Syndrome

Assessment of Aortic Pulse Wave Velocity and Cardiac Diastolic Function in Subjects With and Without the Metabolic Syndrome HDL cholesterol is independently associated with cardiovascular function Stijntje D. Roes , MD 1 , Reza Alizadeh Dehnavi , MD 2 , Jos J.M. Westenberg , PHD 1 , Hildo J. Lamb , MD 1 , Bart J.A. Mertens , PHD 3 , Jouke T. Tamsma , MD 2 and Albert de Roos , MD 1 1 Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands 2 Department of General Internal Medicine and Endocrinology, Leiden University Medical Center, Leiden, the Netherlands 3 Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, the Netherlands Corresponding author: Stijntje D. Roes, s.d.roes{at}lumc.nl Abstract OBJECTIVE —To evaluate the influence of lipid and glucose metabolism in the metabolic syndrome on aortic pulse wave velocity (PWV) and left ventricular (LV) diastolic function using magnetic resonance imaging (MRI). RESEARCH DESIGN AND METHODS —Aortic PWV and LV diastolic function were assessed using MRI in 16 subjects with the metabolic syndrome and 16 subjects without the metabolic syndrome matched for age, waist circumference, and blood pressure. The groups were compared using the unpaired t test or Mann-Whitney U test, and linear regression analysis was applied. RESULTS —Aortic PWV was increased and LV diastolic function was decreased in subjects with compared with those without the metabolic syndrome. HDL cholesterol was independently associated with aortic PWV ( R = −0.470, P < 0.01) and LV diastolic function ( R = −0.421, P = 0.02). CONCLUSIONS —Increased aortic PWV and decreased LV diastolic function is observed in subjects with the metabolic syndrome, regardless of blood pressure. Moreover, HDL cholesterol is independently associated with aortic PWV and LV diastolic function. Footnotes Published ahead of print at http://care.diabetesjournals.org on 8 April 2008. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C Section 1734 solely to indicate this fact. Accepted April 2, 2008. Received January 9, 2008. DIABETES CARE