Continuous Glucose Monitoring–Guided Insulin Adjustment in Children and Adolescents on Near-Physiological Insulin Regimens

Continuous Glucose Monitoring–Guided Insulin Adjustment in Children and Adolescents on Near-Physiological Insulin Regimens A randomized controlled trial Kylie Yates , MBBS, FRACP 1 , Abul Hasnat Milton , PHD 2 , Keith Dear , PHD 3 and Geoffrey Ambler , MD, FRACP 1 1 Institute of Endocrinology and Diabetes, The Children’s Hospital at Westmead, Westmead, NSW, Australia 2 Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, Australia 3 National Centre for Epidemiology and Population Health, Australian National University, Canberra, Australia Address correspondence and reprint requests to Kylie Yates, MBBS, FRACP, Institute of EndocrinologyDiabetes, The Children’s Hospital, Westmead, Locked Bag 4001, Westmead, NSW 2145, Australia. E-mail: kyliey{at}chw.edu.au Abstract OBJECTIVE —This randomized controlled trial assesses the effect on glycemic control of continuous glucose monitoring system (CGMS)-guided insulin therapy adjustment in young people with type 1 diabetes on intensive diabetes treatment regimens with continuous subcutaneous insulin infusion (CSII) or glargine. RESEARCH DESIGN AND METHODS —Pediatric subjects were recruited if they had an HbA 1c (A1C)