1720-P: Metabolic Response to Bariatric Surgery of Novel High-Risk Prediabetes Subphenotypes

A novel pathophysiology-based method to subphenotype individuals at elevated risk for type 2 diabetes has recently identified 6 subgroups, 2 of which constitute obese, high-risk subpopulations with different glycemic, renal, cardiovascular and all-cause mortality risk profiles. The aim of our study was to evaluate differences in response to weight-loss surgery between these clusters, termed clusters 5 & 6 by Wagner et al. We performed this clustering on the Bialystok Bariatric Surgery Study Cohort consisting of nondiabetic patients with at least one year of follow-up data who underwent sleeve gastrectomy surgery. We used generalized linear models to test for differences between clusters in baseline parameters and changes after one year. At baseline, 48 (47%) patients were classified as cluster 5 and 54 (53%) as cluster 6. Before the surgery, cluster 5 subjects had significantly (q-value