1008-P: 3D Acoustic Radiation Force Impulse Virtual Imaging of Whole Human Abdominal Subcutaneous Tissue Imaging with “Insulin Ball”

Introduction: Current evidence suggests that subcutaneous “insulin ball”, a feature of the tissue-dystrophy, provokes hormonal perturbation in insulin absorption. Unforeseen 3-dimension (3D) whole human abdominal subcutaneous tissue within the insulin injecting subjects, we tried to elucidate a novel 3D ultrasound acoustic radiation force impulse (3D-ARFI) to quantitates the entire “tissue-dystrophy” volume in human. Methods: Seven patients with daily insulin injected diabetes were enrolled and the 3D-ARFI was applied to measure tissue displacement. To generate the elasticity gradients along the depth axis of the whole abdominal subcutaneous tissue, we compared lateral region of the abdomen as internal-control. A subcutaneous insulin tolerance test was conducted to validate the rate of insulin absorption at the site of the tissue-dystrophyand control. We also analyzed the volume of whole insulin induced tissue-dystrophy with entire abdominal wall volume governed by consecutive ARFI slice imaging. Results: Subcutaneous tissue stiffness measured by ARFI revealed that ARFI enabled the elastic characterization (p