Replication of Previously Type 2 Diabetes Associated Loci in 35,000 Samples of Korean Population

In the last decade, genome-wide association studies (GWAS) have revealed about hundreds of loci associated with type 2 diabetes(T2D) and related traits. However, most of loci have been discovered based on Europeans and a few GWAS conducted in populations with East Asian ancestry. To identify genetic variants responsible for complex traits such as T2D, obesity, and blood biochemical traits in Koreans, Korea Biobank Array(KBA) project was initiated in 2014. KBA is designed to contain about 830K tagging and functional variants optimized for Korean genome. In this study, quality controlled genotype data of about 35,000 samples was used. Among them, we conducted genome-wide association scan in 3,022 T2D case subjects and 27,195 control subjects. As a result, we replicated five previously known loci (CDKAL1, SLC30A8, CDKN2A, KCNQ1, and HNF1B) at genome-wide significance (P