More Subjects Achieved Composite Reductions of =1% HbA1c, =5% Body Weight, and =5 mmHg SBP with Semaglutide vs. Comparators (SUSTAIN 1-5, 7)

Semaglutide is a new GLP-1 analog for the once-weekly treatment of type 2 diabetes (T2D). Across the SUSTAIN clinical trial program, subjects with T2D achieved significantly greater reductions in three cardiovascular (CV) risk factors with semaglutide vs. placebo or comparators (dulaglutide, exenatide extended release, insulin glargine, or sitagliptin): HbA1c, body weight and systolic blood pressure (SBP). Six SUSTAIN trials (SUSTAIN 1-5 and 7) were assessed post-hoc to determine to what extent subjects achieved clinically meaningful reductions in all of these risk factors (composite endpoint: ≥1% decrease in HbA1c, ≥5% body weight loss, and ≥5 mmHg SBP reduction). Across trials, mean baseline HbA1c, body weight and SBP ranges were 8.1-8.4%, 89.5-95.8 kg and 128.8-134.8 mmHg, respectively. Significantly more subjects achieved the composite endpoint with semaglutide (0.5 mg: 14-20%; 1.0 mg: 15-37%) vs. comparators (1-12%; p