Evidence of Interaction Between PPARG2 and HNF4 A Contributing to Variation in Insulin Sensitivity in Mexican Americans

Evidence of Interaction Between PPARG2 and HNF4 A Contributing to Variation in Insulin Sensitivity in Mexican Americans

OBJECTIVE—We hypothesized that interaction between PPARG2 Pro12Ala and variants in the promoter region of HNF4A are associated with type 2 diabetes–related quantitative traits in Mexican-American families of a proband with previous gestational diabetes. RESEARCH DESIGN AND METHODS—The BetaGene proje...

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Veröffentlicht in:Diabetes (New York, N.Y.) N.Y.), 2008-04, Vol.57 (4), p.1048-1056
Hauptverfasser: Black, Mary Helen, Fingerlin, Tasha E., Allayee, Hooman, Zhang, Weiming, Xiang, Anny H., Trigo, Enrique, Hartiala, Jaana, Lehtinen, Allison B., Haffner, Steven M., Bergman, Richard N., McEachin, Richard C., Kjos, Siri L., Lawrence, Jean M., Buchanan, Thomas A., Watanabe, Richard M.
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Sprache:eng
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Zusammenfassung:OBJECTIVE—We hypothesized that interaction between PPARG2 Pro12Ala and variants in the promoter region of HNF4A are associated with type 2 diabetes–related quantitative traits in Mexican-American families of a proband with previous gestational diabetes. RESEARCH DESIGN AND METHODS—The BetaGene project genotyped PPARG2 Pro12Ala and nine HNF4A single nucleotide polymorphisms (SNPs) in 473 individuals in 89 families. Members of the proband generation had fasting glucose
ISSN:0012-1797
1939-327X
DOI:10.2337/db07-0848