Expression of Cannabinoid Receptor GPR55 in Human Gingival Fibroblasts and Anti-inflammatory Effects of Cannabidiol via GPR55

Cannabidiol (CBD) in cannabis has an anti-inflammatory effect, and its receptor, G protein-coupled receptor 55 (GPR55), has been suggested to be involved in the regulation of inflammation. Here, we investigated GPR55 expression in human gingival fibroblasts (HGFs) and anti-inflammatory effects of CB...

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Veröffentlicht in:	Journal of the Japanese Society of Periodontology 2021/03/31, Vol.63(1), pp.11-23
Hauptverfasser:	Mishiro, Saki, Igarashi-Takeuchi, Hiroko, Numabe, Yukihiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-inflammatory effects Cannabidiol Cytokines G protein-coupled receptor 55 Human gingival fibroblasts
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Zusammenfassung:	Cannabidiol (CBD) in cannabis has an anti-inflammatory effect, and its receptor, G protein-coupled receptor 55 (GPR55), has been suggested to be involved in the regulation of inflammation. Here, we investigated GPR55 expression in human gingival fibroblasts (HGFs) and anti-inflammatory effects of CBD via GPR55.GPR55 expression and localization were confirmed in control, LPS-stimulated (LPS), CBD-treated and LPS-stimulated (CBD+LPS), and CBD-treated (CBD) groups. We also compared interleukin (IL) -6 and IL-8 protein production in each group.GPR55 expression levels were significantly reduced in the LPS and CBD+LPS groups (p
ISSN:	0385-0110 1880-408X
DOI:	10.2329/perio.63.11