Basic study of the Effects of Minocycline HCl on Periodontally-involved Root Surfaces

The acid conditioning effects of minocycline on the root surface with mechanical root cleaning were investigated in this study. Root surface specimens were randomly assigned to scaling group (control), polishing group (polish), superficial debridement group (SL) and deep debridement group (DL) with minocycline solution (10mg/ml). The antimicrobial activities of minocycline solution (10mg/ml, 10min) against P. gingivalis, by moniforing penetration rate and attachment rate were evaluated. The results showed that all groups possessed antimicrobial activity against P. gingivalis on days 0 and 7 after root conditioning with minocycline solution (10mg/ml, 10 min). Especially, DL group exhibited significantly higher antimicrobial activity (Day 0: average 94.8 unit [p