One Hundred Percent Tumor Induction in Mouse Skin after Repeated β Irradiation in a Limited Dose Range
Repeated β irradiation of the backs of mice three times a week with radiation doses of 250 to 1180 cGy per exposure induced 100% incidence of tumors. The incidence of skin tumors appeared to be determined by the total number of repeated exposures in this dose range. An abrupt delay in tumor emergenc...
Gespeichert in:
| Veröffentlicht in: | Radiation research 1988-09, Vol.115 (3), p.488-494 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 494 |
|---|---|
| container_issue | 3 |
| container_start_page | 488 |
| container_title | Radiation research |
| container_volume | 115 |
| creator | Ootsuyama, Akira Tanooka, Hiroshi |
| description | Repeated β irradiation of the backs of mice three times a week with radiation doses of 250 to 1180 cGy per exposure induced 100% incidence of tumors. The incidence of skin tumors appeared to be determined by the total number of repeated exposures in this dose range. An abrupt delay in tumor emergence was observed when the radiation dose was reduced from 250 to 150 cGy per exposure, indicating the existence of a critical threshold. Mouse skin resembles human skin rather than rat skin in its response to radiation. |
| doi_str_mv | 10.2307/3577298 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_cross</sourceid><recordid>TN_cdi_crossref_primary_10_2307_3577298</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>3577298</jstor_id><sourcerecordid>3577298</sourcerecordid><originalsourceid>FETCH-LOGICAL-c249t-9c47259c44d8dd4d4db42f6465dfef27e8141dcce8d668f0baa87ef7470129a33</originalsourceid><addsrcrecordid>eNp1kMtKAzEUhoMotVbxCYQsBFejuc0kWUq9tFCp1Loe0lzK1DZTkpmFr-WD-EymdKwrOXAu_N85B34ALjG6JRTxO5pzTqQ4An0sqchyhtgx6CNEacZzwU_BWYwrlGZcyB7oUcyZpKQPllNv4aj1JlgDX23Q1jdw3m7qAMfetLqpag8rD1_qNlr49pFa5Rob4MxurWrS0vcXHIegTKV-WQUn1abaaQ91Wpopv7Tn4MSpdbQXXR2A96fH-XCUTabP4-H9JNOEySaTmnGSp8yMMIalWDDiClbkxllHuBWYYaO1FaYohEMLpQS3jjOOMJGK0gG42d_VoY4xWFduQ7VR4bPEqNw5VXZOJfJqT27bxcaaA9dZk_TrTldRq7ULyusqHrBC8oII9oetYlOHf7_9AATSe0w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>One Hundred Percent Tumor Induction in Mouse Skin after Repeated β Irradiation in a Limited Dose Range</title><source>Jstor Complete Legacy</source><source>MEDLINE</source><creator>Ootsuyama, Akira ; Tanooka, Hiroshi</creator><creatorcontrib>Ootsuyama, Akira ; Tanooka, Hiroshi</creatorcontrib><description>Repeated β irradiation of the backs of mice three times a week with radiation doses of 250 to 1180 cGy per exposure induced 100% incidence of tumors. The incidence of skin tumors appeared to be determined by the total number of repeated exposures in this dose range. An abrupt delay in tumor emergence was observed when the radiation dose was reduced from 250 to 150 cGy per exposure, indicating the existence of a critical threshold. Mouse skin resembles human skin rather than rat skin in its response to radiation.</description><identifier>ISSN: 0033-7587</identifier><identifier>EISSN: 1938-5404</identifier><identifier>DOI: 10.2307/3577298</identifier><identifier>PMID: 3174932</identifier><identifier>CODEN: RAREAE</identifier><language>eng</language><publisher>Oak Brook, Il: Academic Press, Inc</publisher><subject>Animal tumors. Experimental tumors ; Animals ; Beta Particles ; Biological and medical sciences ; Cancer ; Carcinoma, Basal Cell - etiology ; Carcinoma, Squamous Cell - etiology ; Dosage ; Dose fractionation ; Dose-Response Relationship, Radiation ; Experimental skin tumors ; Female ; Fibrosarcoma - etiology ; Ionizing radiation ; Irradiation ; Kinetics ; Medical sciences ; Mice ; Mice, Inbred ICR ; Neoplasms, Radiation-Induced ; Osteosarcoma - etiology ; Radiation damage ; Radiation dosage ; Radiotherapy ; Skin cancers ; Skin Neoplasms - etiology ; Tumors</subject><ispartof>Radiation research, 1988-09, Vol.115 (3), p.488-494</ispartof><rights>Copyright 1988 Academic Press, Inc.</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c249t-9c47259c44d8dd4d4db42f6465dfef27e8141dcce8d668f0baa87ef7470129a33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3577298$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3577298$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6976284$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3174932$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ootsuyama, Akira</creatorcontrib><creatorcontrib>Tanooka, Hiroshi</creatorcontrib><title>One Hundred Percent Tumor Induction in Mouse Skin after Repeated β Irradiation in a Limited Dose Range</title><title>Radiation research</title><addtitle>Radiat Res</addtitle><description>Repeated β irradiation of the backs of mice three times a week with radiation doses of 250 to 1180 cGy per exposure induced 100% incidence of tumors. The incidence of skin tumors appeared to be determined by the total number of repeated exposures in this dose range. An abrupt delay in tumor emergence was observed when the radiation dose was reduced from 250 to 150 cGy per exposure, indicating the existence of a critical threshold. Mouse skin resembles human skin rather than rat skin in its response to radiation.</description><subject>Animal tumors. Experimental tumors</subject><subject>Animals</subject><subject>Beta Particles</subject><subject>Biological and medical sciences</subject><subject>Cancer</subject><subject>Carcinoma, Basal Cell - etiology</subject><subject>Carcinoma, Squamous Cell - etiology</subject><subject>Dosage</subject><subject>Dose fractionation</subject><subject>Dose-Response Relationship, Radiation</subject><subject>Experimental skin tumors</subject><subject>Female</subject><subject>Fibrosarcoma - etiology</subject><subject>Ionizing radiation</subject><subject>Irradiation</subject><subject>Kinetics</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Neoplasms, Radiation-Induced</subject><subject>Osteosarcoma - etiology</subject><subject>Radiation damage</subject><subject>Radiation dosage</subject><subject>Radiotherapy</subject><subject>Skin cancers</subject><subject>Skin Neoplasms - etiology</subject><subject>Tumors</subject><issn>0033-7587</issn><issn>1938-5404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtKAzEUhoMotVbxCYQsBFejuc0kWUq9tFCp1Loe0lzK1DZTkpmFr-WD-EymdKwrOXAu_N85B34ALjG6JRTxO5pzTqQ4An0sqchyhtgx6CNEacZzwU_BWYwrlGZcyB7oUcyZpKQPllNv4aj1JlgDX23Q1jdw3m7qAMfetLqpag8rD1_qNlr49pFa5Rob4MxurWrS0vcXHIegTKV-WQUn1abaaQ91Wpopv7Tn4MSpdbQXXR2A96fH-XCUTabP4-H9JNOEySaTmnGSp8yMMIalWDDiClbkxllHuBWYYaO1FaYohEMLpQS3jjOOMJGK0gG42d_VoY4xWFduQ7VR4bPEqNw5VXZOJfJqT27bxcaaA9dZk_TrTldRq7ULyusqHrBC8oII9oetYlOHf7_9AATSe0w</recordid><startdate>198809</startdate><enddate>198809</enddate><creator>Ootsuyama, Akira</creator><creator>Tanooka, Hiroshi</creator><general>Academic Press, Inc</general><general>Radiation Research Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>198809</creationdate><title>One Hundred Percent Tumor Induction in Mouse Skin after Repeated β Irradiation in a Limited Dose Range</title><author>Ootsuyama, Akira ; Tanooka, Hiroshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c249t-9c47259c44d8dd4d4db42f6465dfef27e8141dcce8d668f0baa87ef7470129a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Animal tumors. Experimental tumors</topic><topic>Animals</topic><topic>Beta Particles</topic><topic>Biological and medical sciences</topic><topic>Cancer</topic><topic>Carcinoma, Basal Cell - etiology</topic><topic>Carcinoma, Squamous Cell - etiology</topic><topic>Dosage</topic><topic>Dose fractionation</topic><topic>Dose-Response Relationship, Radiation</topic><topic>Experimental skin tumors</topic><topic>Female</topic><topic>Fibrosarcoma - etiology</topic><topic>Ionizing radiation</topic><topic>Irradiation</topic><topic>Kinetics</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>Neoplasms, Radiation-Induced</topic><topic>Osteosarcoma - etiology</topic><topic>Radiation damage</topic><topic>Radiation dosage</topic><topic>Radiotherapy</topic><topic>Skin cancers</topic><topic>Skin Neoplasms - etiology</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ootsuyama, Akira</creatorcontrib><creatorcontrib>Tanooka, Hiroshi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Radiation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ootsuyama, Akira</au><au>Tanooka, Hiroshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>One Hundred Percent Tumor Induction in Mouse Skin after Repeated β Irradiation in a Limited Dose Range</atitle><jtitle>Radiation research</jtitle><addtitle>Radiat Res</addtitle><date>1988-09</date><risdate>1988</risdate><volume>115</volume><issue>3</issue><spage>488</spage><epage>494</epage><pages>488-494</pages><issn>0033-7587</issn><eissn>1938-5404</eissn><coden>RAREAE</coden><abstract>Repeated β irradiation of the backs of mice three times a week with radiation doses of 250 to 1180 cGy per exposure induced 100% incidence of tumors. The incidence of skin tumors appeared to be determined by the total number of repeated exposures in this dose range. An abrupt delay in tumor emergence was observed when the radiation dose was reduced from 250 to 150 cGy per exposure, indicating the existence of a critical threshold. Mouse skin resembles human skin rather than rat skin in its response to radiation.</abstract><cop>Oak Brook, Il</cop><pub>Academic Press, Inc</pub><pmid>3174932</pmid><doi>10.2307/3577298</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0033-7587 |
| ispartof | Radiation research, 1988-09, Vol.115 (3), p.488-494 |
| issn | 0033-7587 1938-5404 |
| language | eng |
| recordid | cdi_crossref_primary_10_2307_3577298 |
| source | Jstor Complete Legacy; MEDLINE |
| subjects | Animal tumors. Experimental tumors Animals Beta Particles Biological and medical sciences Cancer Carcinoma, Basal Cell - etiology Carcinoma, Squamous Cell - etiology Dosage Dose fractionation Dose-Response Relationship, Radiation Experimental skin tumors Female Fibrosarcoma - etiology Ionizing radiation Irradiation Kinetics Medical sciences Mice Mice, Inbred ICR Neoplasms, Radiation-Induced Osteosarcoma - etiology Radiation damage Radiation dosage Radiotherapy Skin cancers Skin Neoplasms - etiology Tumors |
| title | One Hundred Percent Tumor Induction in Mouse Skin after Repeated β Irradiation in a Limited Dose Range |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T06%3A50%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=One%20Hundred%20Percent%20Tumor%20Induction%20in%20Mouse%20Skin%20after%20Repeated%20%CE%B2%20Irradiation%20in%20a%20Limited%20Dose%20Range&rft.jtitle=Radiation%20research&rft.au=Ootsuyama,%20Akira&rft.date=1988-09&rft.volume=115&rft.issue=3&rft.spage=488&rft.epage=494&rft.pages=488-494&rft.issn=0033-7587&rft.eissn=1938-5404&rft.coden=RAREAE&rft_id=info:doi/10.2307/3577298&rft_dat=%3Cjstor_cross%3E3577298%3C/jstor_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/3174932&rft_jstor_id=3577298&rfr_iscdi=true |