One Hundred Percent Tumor Induction in Mouse Skin after Repeated β Irradiation in a Limited Dose Range

Repeated β irradiation of the backs of mice three times a week with radiation doses of 250 to 1180 cGy per exposure induced 100% incidence of tumors. The incidence of skin tumors appeared to be determined by the total number of repeated exposures in this dose range. An abrupt delay in tumor emergenc...

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Veröffentlicht in:	Radiation research 1988-09, Vol.115 (3), p.488-494
Hauptverfasser:	Ootsuyama, Akira, Tanooka, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal tumors. Experimental tumors Animals Beta Particles Biological and medical sciences Cancer Carcinoma, Basal Cell - etiology Carcinoma, Squamous Cell - etiology Dosage Dose fractionation Dose-Response Relationship, Radiation Experimental skin tumors Female Fibrosarcoma - etiology Ionizing radiation Irradiation Kinetics Medical sciences Mice Mice, Inbred ICR Neoplasms, Radiation-Induced Osteosarcoma - etiology Radiation damage Radiation dosage Radiotherapy Skin cancers Skin Neoplasms - etiology Tumors
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Beschreibung
Zusammenfassung:	Repeated β irradiation of the backs of mice three times a week with radiation doses of 250 to 1180 cGy per exposure induced 100% incidence of tumors. The incidence of skin tumors appeared to be determined by the total number of repeated exposures in this dose range. An abrupt delay in tumor emergence was observed when the radiation dose was reduced from 250 to 150 cGy per exposure, indicating the existence of a critical threshold. Mouse skin resembles human skin rather than rat skin in its response to radiation.
ISSN:	0033-7587 1938-5404
DOI:	10.2307/3577298