Life Span and Tumor Incidence in Rats Receiving Postradiation Treatment with ATP-AET-Mexamine Mixture

Rat females were exposed to a single 4.0-Gy γ-ray dose and treated postradiation with a mixture of ATP-AET-mexamine at daily doses of 24, 12, and 3 mg/kg body wt, respectively, in drinking water throughout the period of their survival. With the radiation dose used, life shortening appeared primarily...

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Veröffentlicht in:	Radiat. Res.; (United States) 1985-01, Vol.101 (1), p.207-211
Hauptverfasser:	Benova, D. K., Kiradzhiev, G. D., Troitskaya, M. N., Anisimov, V. N.
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Methoxytryptamine - administration & dosage 560152 - Radiation Effects on Animals- Animals Adenosine Triphosphate - administration & dosage AET ALKALI METAL ISOTOPES AMINES ANIMALS ATP BETA DECAY RADIOISOTOPES beta-Aminoethyl Isothiourea - administration & dosage BETA-MINUS DECAY RADIOISOTOPES BIOLOGICAL EFFECTS BIOLOGICAL RADIATION EFFECTS CARBONIC ACID DERIVATIVES CESIUM 137 CESIUM ISOTOPES Chemical mixtures Correspondence DELAYED RADIATION EFFECTS DISEASE INCIDENCE DISEASES DRINKING WATER Drug Therapy, Combination DRUGS ELECTROMAGNETIC RADIATION ETHERS Female FEMALES Fibroadenoma GAMMA RADIATION HYDROGEN COMPOUNDS IONIZING RADIATIONS ISOTOPES LIFE SPAN MAMMALS Mammary glands MEXAMINE NEOPLASMS Neoplasms, Radiation-Induced - prevention & control NUCLEI NUCLEOTIDES ODD-EVEN NUCLEI ORGANIC COMPOUNDS ORGANIC OXYGEN COMPOUNDS ORGANIC SULFUR COMPOUNDS OXYGEN COMPOUNDS Potable water Protectors RADIATION EFFECTS Radiation Injuries, Experimental - prevention & control RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT Radiation-Protective Agents - therapeutic use RADIATIONS RADIOINDUCTION RADIOISOTOPES Radioprotective agents RADIOPROTECTIVE SUBSTANCES RADIOSENSITIVITY EFFECTS Radiotherapy RATS Rats, Inbred Strains RODENTS THIOUREAS Tumors VERTEBRATES WATER YEARS LIVING RADIOISOTOPES
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Beschreibung
Zusammenfassung:	Rat females were exposed to a single 4.0-Gy γ-ray dose and treated postradiation with a mixture of ATP-AET-mexamine at daily doses of 24, 12, and 3 mg/kg body wt, respectively, in drinking water throughout the period of their survival. With the radiation dose used, life shortening appeared primarily attributable to nonstochastic effects. The mixture of chemical protectors failed to show modification of long-term radiation effects with regard to either life span or tumor incidence.
ISSN:	0033-7587 1938-5404
DOI:	10.2307/3576317