Cysteamine as a Protective Agent with High-LET Radiations

Experiments to measure the radiation protection of cysteamine for high-LET radiations were carried out with synchronized Chinese hamster V79 cells. A high concentration (75 mM) of cysteamine was found to provide protection against X rays and 90 and 170 ke V/μm helium ions. The extent of protection d...

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Veröffentlicht in:	Radiat. Res.; (United States) 1980-05, Vol.82 (2), p.290-296
1. Verfasser:	Bird, Richard P.
Format:	Artikel
Sprache:	eng
Schlagworte:	560121 - Radiation Effects on Cells- External Source- (-1987) Alpha Particles AMINES ANIMALS BIOLOGICAL EFFECTS BIOLOGICAL RADIATION EFFECTS CELL CULTURES Cell cycle Cell Line Cell Survival - drug effects Cell Survival - radiation effects Cricetinae Cricetulus Cultured cells Cysteamine - pharmacology Dose-Response Relationship, Radiation DOSE-RESPONSE RELATIONSHIPS DOSES DRUGS ELECTROMAGNETIC RADIATION ENERGY TRANSFER HAMSTERS Helium HELIUM IONS Interphase - drug effects Interphase - radiation effects IONIZING RADIATIONS Irradiation LET MAMMALS MEA ORGANIC COMPOUNDS ORGANIC SULFUR COMPOUNDS Protective agents Radiation dosage RADIATION DOSES RADIATION EFFECTS RADIATION PROTECTION Radiation Tolerance RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIATIONS RADIOPROTECTIVE SUBSTANCES RADIOSENSITIVITY RADIOSENSITIVITY EFFECTS Radiotherapy Research facilities RESPONSE MODIFYING FACTORS RODENTS Solar X rays SURVIVAL CURVES SYNCHRONOUS CULTURES THIOLS VERTEBRATES X RADIATION X-Rays
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Zusammenfassung:	Experiments to measure the radiation protection of cysteamine for high-LET radiations were carried out with synchronized Chinese hamster V79 cells. A high concentration (75 mM) of cysteamine was found to provide protection against X rays and 90 and 170 ke V/μm helium ions. The extent of protection decreased with increased LET value but was substantial with the highest-LET radiation. Thus the approximate dose-modifying factor for G1/ S cells was decreased from 4.8 to 1.6 and for late-S cells from 3.2 to 1.5. The shape of the high-LET survival curves for both cell cycle times was preserved as expected for a dose-modifying agent.
ISSN:	0033-7587 1938-5404
DOI:	10.2307/3575380