Effects of Low-Dose Radiation on Repair Processes in Human Lymphocytes

DNA excision repair was investigated in lymphocytes of persons occupationally exposed to low-dose radiation from 222 Rn. Autoradiographic studies of unscheduled DNA synthesis and measurement of [3 H] thymidine incorporation by repair replication into double-stranded and single-strand-containing DNA...

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Veröffentlicht in:	Radiat. Res.; (United States) 1980-01, Vol.81 (1), p.1-9
Hauptverfasser:	Tuschl, Helga, Altmann, Hans, Kovac, Rozi, Topaloglou, Alexander, Egg, Dietmar, Günther, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	550400 - Genetics 552000 - Public Health 560121 - Radiation Effects on Cells- External Source- (-1987) Adult ALPHA DECAY RADIOISOTOPES ANIMAL CELLS AZINES B lymphocytes BASIC BIOLOGICAL SCIENCES BETA DECAY RADIOISOTOPES BETA-MINUS DECAY RADIOISOTOPES BIOLOGICAL EFFECTS BIOLOGICAL MATERIALS BIOLOGICAL RADIATION EFFECTS BIOLOGICAL RECOVERY BIOLOGICAL REPAIR BIOSYNTHESIS BLOOD BLOOD CELLS BODY FLUIDS Cells, Cultured Cellular differentiation CONNECTIVE TISSUE CELLS DAYS LIVING RADIOISOTOPES DNA DNA damage DNA Repair Environmental Exposure ENZYMES EVEN-EVEN NUCLEI GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE HEAVY NUCLEI HETEROCYCLIC COMPOUNDS Humans HYDROGEN ISOTOPES Hydroxyurea - pharmacology INDUSTRIAL MEDICINE IRRADIATION ISOTOPE APPLICATIONS ISOTOPES LEUKOCYTES LIGHT NUCLEI LOW DOSE IRRADIATION LYMPHOCYTES Lymphocytes - drug effects Lymphocytes - metabolism Lymphocytes - radiation effects MATERIALS MEDICINE Middle Aged NUCLEI NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ODD-EVEN NUCLEI ORGANIC COMPOUNDS ORGANIC NITROGEN COMPOUNDS PERSONNEL PYRIMIDINES Radiation damage Radiation Dosage RADIATION EFFECTS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIOISOTOPES RADIOLOGICAL PERSONNEL RADIOSENSITIVITY Radon RADON 222 RADON ISOTOPES RECOVERY REPAIR RIBOSIDES SOMATIC CELLS SYNTHESIS T lymphocytes THYMIDINE TRITIUM YEARS LIVING RADIOISOTOPES
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Beschreibung
Zusammenfassung:	DNA excision repair was investigated in lymphocytes of persons occupationally exposed to low-dose radiation from 222 Rn. Autoradiographic studies of unscheduled DNA synthesis and measurement of [3 H] thymidine incorporation by repair replication into double-stranded and single-strand-containing DNA fractions obtained by BND cellulose chromatography seem to indicate a stimulator effect of repeated low-dose irradiation on repair enzymes.
ISSN:	0033-7587 1938-5404
DOI:	10.2307/3575358