A Parametric Method for Estimation of Dose-Modifying Factors: Low-Dose Extrapolation Limit

A parametric method for the estimation of dose-modifying factors (DMF) is developed, using the linear-quadratic model of radiation effect. The method presented here generalizes DMFs to include ratios, such as relative biological effectiveness (RBE), which may vary with dose. A statistical test for c...

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Veröffentlicht in:	Radiat. Res.; (United States) 1977-01, Vol.69 (1), p.1-15
Hauptverfasser:	McLarty, Jerry W., Thames, Howard D.
Format:	Artikel
Sprache:	eng
Schlagworte:	560121 - Radiation Effects on Cells- External Source- (-1987) ANIMAL CELLS BARYONS BETA DECAY RADIOISOTOPES BETA-MINUS DECAY RADIOISOTOPES BIOLOGICAL EFFECTS BIOLOGICAL RADIATION EFFECTS Cell Survival - radiation effects COBALT 60 COBALT ISOTOPES Cobalt Radioisotopes Confidence interval Confidence limits Dose-Response Relationship, Radiation DOSE-RESPONSE RELATIONSHIPS DOSIMETRY ELECTROMAGNETIC RADIATION ELEMENTARY PARTICLES Estimation methods Fast Neutrons FERMIONS GAMMA RADIATION HADRONS INTERMEDIATE MASS NUCLEI INTERNAL CONVERSION RADIOISOTOPES IONIZING RADIATIONS IRRADIATION ISOMERIC TRANSITION ISOTOPES ISOTOPES LOW DOSE IRRADIATION Mathematical extrapolation MATHEMATICS MINUTES LIVING RADIOISOTOPES NEUTRONS NUCLEI NUCLEONS ODD-ODD NUCLEI Parametric models Radiation dosage RADIATION EFFECTS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIATIONS RADIOISOTOPES Radiotherapy Radiotherapy Dosage Radiotherapy, High-Energy RBE Relative Biological Effectiveness Statistical discrepancies STATISTICS SURVIVAL TIME YEARS LIVING RADIOISOTOPES
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Zusammenfassung:	A parametric method for the estimation of dose-modifying factors (DMF) is developed, using the linear-quadratic model of radiation effect. The method presented here generalizes DMFs to include ratios, such as relative biological effectiveness (RBE), which may vary with dose. A statistical test for constant DMF is derived and a limit to reliable low-dose extrapolation of estimates of the DMF is presented. The relationship of the method presented here to the usual "straight-line" method, and a recently developed nonparametric method is discussed. Using cell survival data for 16-MeV neutrons and 60 Co, the RBE of 16-MeV neutrons is computed by all three methods for comparison.
ISSN:	0033-7587 1938-5404
DOI:	10.2307/3574512