Effect of X-Irradiation on Gene Function in Bacteriophage T4

The effect of x-irradiation on gene function in bacteriophage T4 was examined using amber mutants for gene complementation. "Early" functions tested were less sensitive to x-rays than "late" functions. Both early and late functions were stabilized in chloramphenicol-pretreated co...

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Veröffentlicht in:	Radiat. Res. 43: 379-92(Aug 1970) 1970-08, Vol.43 (2), p.379-392
Hauptverfasser:	Wallace, Susan S., van Dyke, James G.
Format:	Artikel
Sprache:	eng
Schlagworte:	ANTIBIOTICS Bacteria Bacteriophage T4 BACTERIOPHAGES BACTERIOPHAGES/T4, radiosensitivity of gene function in, effects of pretreatment with chloramphenicol or cyanide on x Beryllium CHLORAMPHENICOL Chloramphenicol - pharmacology CHLORAMPHENICOL/effects on x-radiosensitivity of gene function in bacteriophage T4 CHROMOSOMES Coliphages - drug effects Coliphages - radiation effects CYANIDES Cyanides - pharmacology CYANIDES/effects on x-radiosensitivity of gene function in bacteriophage T4 DNA DNA damage GENES Genes - drug effects Genes - radiation effects GENES/radiosensitivity of bacteriophage T4, effects of pretreatment with chloramphenicol or cyanide on x Genetic Code GENETICS Genetics, Microbial Genomes Irradiation Messenger RNA Models, Biological Mutation N28300 -Life Sciences-Genetics & Cytogenetics N28800 - Life Sciences-Radiation Effects on Microorganisms PHYSIOLOGY Radiation damage Radiation Genetics Radioisotopes RADIOSENSITIVITY VARIATIONS X RADIATION X RADIATION/effects on gene function in bacteriophage T4, effects of chloramphenicol or cyanide pretreatment on sensitivity to
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Beschreibung
Zusammenfassung:	The effect of x-irradiation on gene function in bacteriophage T4 was examined using amber mutants for gene complementation. "Early" functions tested were less sensitive to x-rays than "late" functions. Both early and late functions were stabilized in chloramphenicol-pretreated complexes, but early functions were stabilized to a much greater extent. A model for phage radiation inactivation is proposed which relates the survival of gene function to the survival of the intact bacteriophage.
ISSN:	0033-7587 1938-5404
DOI:	10.2307/3573042