Antibody Responses in Rhesus Monkeys Exposed to Whole-Body X-Irradiation
The antibody responses of rhesus monkeys given attenuated Venezuelan equine encephalitis vaccine 24 hours after 400 R of acute whole-body x-irradiation were studied. Hemagglutination-inhibiting (HI) and mouse neutralizing antibody titers were used as indices of the immune response. Mean HI antibody...
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| Veröffentlicht in: | Radiat. Res., 35: 451-7(1968) 35: 451-7(1968), 1968-08, Vol.35 (2), p.451-457 |
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| container_end_page | 457 |
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| container_issue | 2 |
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| container_title | Radiat. Res., 35: 451-7(1968) |
| container_volume | 35 |
| creator | Reynolds, Scott L. Craig, Charles P. Whitford, Howard W. Airhart, Jim Staab, Edward V. |
| description | The antibody responses of rhesus monkeys given attenuated Venezuelan equine encephalitis vaccine 24 hours after 400 R of acute whole-body x-irradiation were studied. Hemagglutination-inhibiting (HI) and mouse neutralizing antibody titers were used as indices of the immune response. Mean HI antibody titers in irradiated monkeys were depressed at 14 and 21 days postvaccination compared with nonirradiated, vaccinated controls. Forty-two days after vaccination, comparable HI titers were observed in irradiated and control monkeys. Neutralizing antibody titers in irradiated monkeys were also lower than in controls at day 14, but by day 28 they were similar to those of the vaccine controls. |
| doi_str_mv | 10.2307/3572391 |
| format | Article |
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Hemagglutination-inhibiting (HI) and mouse neutralizing antibody titers were used as indices of the immune response. Mean HI antibody titers in irradiated monkeys were depressed at 14 and 21 days postvaccination compared with nonirradiated, vaccinated controls. Forty-two days after vaccination, comparable HI titers were observed in irradiated and control monkeys. Neutralizing antibody titers in irradiated monkeys were also lower than in controls at day 14, but by day 28 they were similar to those of the vaccine controls.</description><identifier>ISSN: 0033-7587</identifier><identifier>EISSN: 1938-5404</identifier><identifier>DOI: 10.2307/3572391</identifier><identifier>PMID: 4969616</identifier><language>eng</language><publisher>United States: Academic Press, Inc</publisher><subject>Animals ; ANTIBODIES ; ANTIBODIES/radiation effects on formation of, in monkeys, whole- body x ; Antibody formation ; Antibody Formation - radiation effects ; ANTIGENS ; BIOSYNTHESIS ; BODY ; BRAIN ; DISEASES ; Dosimetry ; ENCEPHALITIS ; Haplorhini ; Hemagglutination Inhibition Tests ; IMMUNE REACTIONS/radiation effects on, of monkeys, whole-body x ; IMMUNITY ; Infections ; IRRADIATION ; MONKEYS ; MONKEYS/radiation effects on immune antibody response of Rhesus, whole- body x ; N28150 -Life Sciences-Biochemistry, Physiology, & Molecular Biology-Immunology ; Neutralization Tests ; Neutralizing antibodies ; RADIATION DOSES ; RADIATION EFFECTS ; Radiation Injuries, Experimental - immunology ; TESTING ; USES ; Vaccination ; VACCINES ; Venezuelan equine encephalomyelitis ; Viral Vaccines ; Viruses ; WHOLE-BODY IRRADIATION ; X RADIATION ; X RADIATION/effects on immune response of monkeys, whole-body</subject><ispartof>Radiat. Res., 35: 451-7(1968), 1968-08, Vol.35 (2), p.451-457</ispartof><rights>Copyright 1968 Academic Press Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c332t-c637bf3fb0ee36dcf9fe8c9d15652b8a1b42167ca0c93b67bac5dc5d3ef6c76e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3572391$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3572391$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,881,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4969616$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/4486319$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Reynolds, Scott L.</creatorcontrib><creatorcontrib>Craig, Charles P.</creatorcontrib><creatorcontrib>Whitford, Howard W.</creatorcontrib><creatorcontrib>Airhart, Jim</creatorcontrib><creatorcontrib>Staab, Edward V.</creatorcontrib><creatorcontrib>Army Medical Unit, Fort Detrick, Md</creatorcontrib><title>Antibody Responses in Rhesus Monkeys Exposed to Whole-Body X-Irradiation</title><title>Radiat. Res., 35: 451-7(1968)</title><addtitle>Radiat Res</addtitle><description>The antibody responses of rhesus monkeys given attenuated Venezuelan equine encephalitis vaccine 24 hours after 400 R of acute whole-body x-irradiation were studied. Hemagglutination-inhibiting (HI) and mouse neutralizing antibody titers were used as indices of the immune response. Mean HI antibody titers in irradiated monkeys were depressed at 14 and 21 days postvaccination compared with nonirradiated, vaccinated controls. Forty-two days after vaccination, comparable HI titers were observed in irradiated and control monkeys. Neutralizing antibody titers in irradiated monkeys were also lower than in controls at day 14, but by day 28 they were similar to those of the vaccine controls.</description><subject>Animals</subject><subject>ANTIBODIES</subject><subject>ANTIBODIES/radiation effects on formation of, in monkeys, whole- body x</subject><subject>Antibody formation</subject><subject>Antibody Formation - radiation effects</subject><subject>ANTIGENS</subject><subject>BIOSYNTHESIS</subject><subject>BODY</subject><subject>BRAIN</subject><subject>DISEASES</subject><subject>Dosimetry</subject><subject>ENCEPHALITIS</subject><subject>Haplorhini</subject><subject>Hemagglutination Inhibition Tests</subject><subject>IMMUNE REACTIONS/radiation effects on, of monkeys, whole-body x</subject><subject>IMMUNITY</subject><subject>Infections</subject><subject>IRRADIATION</subject><subject>MONKEYS</subject><subject>MONKEYS/radiation effects on immune antibody response of Rhesus, whole- body x</subject><subject>N28150 -Life Sciences-Biochemistry, Physiology, & Molecular Biology-Immunology</subject><subject>Neutralization Tests</subject><subject>Neutralizing antibodies</subject><subject>RADIATION DOSES</subject><subject>RADIATION EFFECTS</subject><subject>Radiation Injuries, Experimental - immunology</subject><subject>TESTING</subject><subject>USES</subject><subject>Vaccination</subject><subject>VACCINES</subject><subject>Venezuelan equine encephalomyelitis</subject><subject>Viral Vaccines</subject><subject>Viruses</subject><subject>WHOLE-BODY IRRADIATION</subject><subject>X RADIATION</subject><subject>X RADIATION/effects on immune response of monkeys, whole-body</subject><issn>0033-7587</issn><issn>1938-5404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1968</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMFKw0AQhhdRaq3iEwhBBE_R3Uyymz3WUm2hIhRFbyG7mdDUNhsyW7Bvb0qKN2FgGP5v_sPH2LXgDxFw9QiJikCLEzYUGtIwiXl8yoacA4QqSdU5uyBa8-4WUg_YINZSSyGHbDaufWVcsQ-WSI2rCSmo6mC5QtpR8Orqb9xTMP1pHGEReBd8rtwGw6fDx1c4b9u8qHJfufqSnZX5hvDquEfs43n6PpmFi7eX-WS8CC1A5EMrQZkSSsMRQRa21CWmVhcikUlk0lyYOBJS2ZxbDUYqk9uk6AawlFZJhBG77Xsd-SojW3m0K-vqGq3P4jiV0AkYsfsesq0jarHMmrba5u0-Ezw7-MqOvjrypiebndli8ccdBXX5XZ-vybv235pffnFwIw</recordid><startdate>196808</startdate><enddate>196808</enddate><creator>Reynolds, Scott L.</creator><creator>Craig, Charles P.</creator><creator>Whitford, Howard W.</creator><creator>Airhart, Jim</creator><creator>Staab, Edward V.</creator><general>Academic Press, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>OTOTI</scope></search><sort><creationdate>196808</creationdate><title>Antibody Responses in Rhesus Monkeys Exposed to Whole-Body X-Irradiation</title><author>Reynolds, Scott L. ; Craig, Charles P. ; Whitford, Howard W. ; Airhart, Jim ; Staab, Edward V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-c637bf3fb0ee36dcf9fe8c9d15652b8a1b42167ca0c93b67bac5dc5d3ef6c76e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1968</creationdate><topic>Animals</topic><topic>ANTIBODIES</topic><topic>ANTIBODIES/radiation effects on formation of, in monkeys, whole- body x</topic><topic>Antibody formation</topic><topic>Antibody Formation - radiation effects</topic><topic>ANTIGENS</topic><topic>BIOSYNTHESIS</topic><topic>BODY</topic><topic>BRAIN</topic><topic>DISEASES</topic><topic>Dosimetry</topic><topic>ENCEPHALITIS</topic><topic>Haplorhini</topic><topic>Hemagglutination Inhibition Tests</topic><topic>IMMUNE REACTIONS/radiation effects on, of monkeys, whole-body x</topic><topic>IMMUNITY</topic><topic>Infections</topic><topic>IRRADIATION</topic><topic>MONKEYS</topic><topic>MONKEYS/radiation effects on immune antibody response of Rhesus, whole- body x</topic><topic>N28150 -Life Sciences-Biochemistry, Physiology, & Molecular Biology-Immunology</topic><topic>Neutralization Tests</topic><topic>Neutralizing antibodies</topic><topic>RADIATION DOSES</topic><topic>RADIATION EFFECTS</topic><topic>Radiation Injuries, Experimental - immunology</topic><topic>TESTING</topic><topic>USES</topic><topic>Vaccination</topic><topic>VACCINES</topic><topic>Venezuelan equine encephalomyelitis</topic><topic>Viral Vaccines</topic><topic>Viruses</topic><topic>WHOLE-BODY IRRADIATION</topic><topic>X RADIATION</topic><topic>X RADIATION/effects on immune response of monkeys, whole-body</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Reynolds, Scott L.</creatorcontrib><creatorcontrib>Craig, Charles P.</creatorcontrib><creatorcontrib>Whitford, Howard W.</creatorcontrib><creatorcontrib>Airhart, Jim</creatorcontrib><creatorcontrib>Staab, Edward V.</creatorcontrib><creatorcontrib>Army Medical Unit, Fort Detrick, Md</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>OSTI.GOV</collection><jtitle>Radiat. Res., 35: 451-7(1968)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Reynolds, Scott L.</au><au>Craig, Charles P.</au><au>Whitford, Howard W.</au><au>Airhart, Jim</au><au>Staab, Edward V.</au><aucorp>Army Medical Unit, Fort Detrick, Md</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antibody Responses in Rhesus Monkeys Exposed to Whole-Body X-Irradiation</atitle><jtitle>Radiat. Res., 35: 451-7(1968)</jtitle><addtitle>Radiat Res</addtitle><date>1968-08</date><risdate>1968</risdate><volume>35</volume><issue>2</issue><spage>451</spage><epage>457</epage><pages>451-457</pages><issn>0033-7587</issn><eissn>1938-5404</eissn><abstract>The antibody responses of rhesus monkeys given attenuated Venezuelan equine encephalitis vaccine 24 hours after 400 R of acute whole-body x-irradiation were studied. Hemagglutination-inhibiting (HI) and mouse neutralizing antibody titers were used as indices of the immune response. Mean HI antibody titers in irradiated monkeys were depressed at 14 and 21 days postvaccination compared with nonirradiated, vaccinated controls. Forty-two days after vaccination, comparable HI titers were observed in irradiated and control monkeys. Neutralizing antibody titers in irradiated monkeys were also lower than in controls at day 14, but by day 28 they were similar to those of the vaccine controls.</abstract><cop>United States</cop><pub>Academic Press, Inc</pub><pmid>4969616</pmid><doi>10.2307/3572391</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0033-7587 |
| ispartof | Radiat. Res., 35: 451-7(1968), 1968-08, Vol.35 (2), p.451-457 |
| issn | 0033-7587 1938-5404 |
| language | eng |
| recordid | cdi_crossref_primary_10_2307_3572391 |
| source | Jstor Complete Legacy; MEDLINE |
| subjects | Animals ANTIBODIES ANTIBODIES/radiation effects on formation of, in monkeys, whole- body x Antibody formation Antibody Formation - radiation effects ANTIGENS BIOSYNTHESIS BODY BRAIN DISEASES Dosimetry ENCEPHALITIS Haplorhini Hemagglutination Inhibition Tests IMMUNE REACTIONS/radiation effects on, of monkeys, whole-body x IMMUNITY Infections IRRADIATION MONKEYS MONKEYS/radiation effects on immune antibody response of Rhesus, whole- body x N28150 -Life Sciences-Biochemistry, Physiology, & Molecular Biology-Immunology Neutralization Tests Neutralizing antibodies RADIATION DOSES RADIATION EFFECTS Radiation Injuries, Experimental - immunology TESTING USES Vaccination VACCINES Venezuelan equine encephalomyelitis Viral Vaccines Viruses WHOLE-BODY IRRADIATION X RADIATION X RADIATION/effects on immune response of monkeys, whole-body |
| title | Antibody Responses in Rhesus Monkeys Exposed to Whole-Body X-Irradiation |
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