Sequential Designs in Bioassay

Sequential Designs in Bioassay

Sequential designs are proposed based on an algorithm for sequential optimization. Examples are given including the estimation of the root of a response function in logit or probit bioassay. Under a variety of circumstances, this method for allocating doses seems to achieve full asymptotic efficienc...

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Veröffentlicht in:Biometrics 1990-03, Vol.46 (1), p.103-116
Hauptverfasser: McLeish, D. L., Tosh, D.
Format: Artikel
Sprache:eng
Schlagworte:
Analytical estimating
Bioassay
Biometrics
Estimation methods
Estimators
Mathematical independent variables
Maximum likelihood estimation
Preliminary estimates
Sample size
Statistical variance
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Beschreibung
Zusammenfassung:Sequential designs are proposed based on an algorithm for sequential optimization. Examples are given including the estimation of the root of a response function in logit or probit bioassay. Under a variety of circumstances, this method for allocating doses seems to achieve full asymptotic efficiency of estimation.
ISSN:0006-341X
1541-0420
DOI:10.2307/2531634