Real-Time Detection of Reactive Oxygen Intermediates from Single Microglial Cells

Real-Time Detection of Reactive Oxygen Intermediates from Single Microglial Cells

A study demonstrates that a self-referencing microsensor can detect H2O2 changes in the nano-molar range near the surface of a single microglial cell. The self-referencing technique is unique in providing the ability to measure the microenvironment around a single cell or cluster of cells in real-ti...

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Veröffentlicht in:The Biological bulletin (Lancaster) 2001-10, Vol.201 (2), p.261-262
Hauptverfasser: Twig, Gilad, Jung, Sung-Kwon, Messerli, Mark A., Smith, Peter J. S., Shirihai, Orian S.
Format: Artikel
Sprache:eng
Schlagworte:
Analysis
Animals
Biosensing Techniques
Brain - metabolism
Catalase - metabolism
Cell membranes
Cell research
Cells
Cellular biology
Cytological research
Degeneration
Electrophysiology
Enzymes
Hydrogen Peroxide - metabolism
Macrophage Activation - physiology
Microglia
Microglia - metabolism
Molecules
Nerve degeneration
Nervous system
Neurobiology
Neurons
Oxygen
Rats
Reactive Oxygen Species - metabolism
Rodents
Sensors
Tetradecanoylphorbol Acetate - pharmacology
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Zusammenfassung:A study demonstrates that a self-referencing microsensor can detect H2O2 changes in the nano-molar range near the surface of a single microglial cell. The self-referencing technique is unique in providing the ability to measure the microenvironment around a single cell or cluster of cells in real-time and with high spatial and temporal resolution.
ISSN:0006-3185
1939-8697
DOI:10.2307/1543355