Persistent hyperinsulinemic hypoglicemia of the neonate
Persistent hyperinsulinemic hypoglicemia of the neonate is a rare heterogenous disease (clinically, histologically, metabolically and genetically), which is characterized by inadequatly high insuline rates in the presence of severe hypoglicemia. Hyperinsulinism, rather a syndrome than a disease, of...
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Veröffentlicht in: | Srpski arhiv za celokupno lekarstvo 2004, Vol.132 (suppl. 1), p.97-100 |
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Hauptverfasser: | , , , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Persistent hyperinsulinemic hypoglicemia of the neonate is a rare
heterogenous disease (clinically, histologically, metabolically and
genetically), which is characterized by inadequatly high insuline rates in
the presence of severe hypoglicemia. Hyperinsulinism, rather a syndrome than
a disease, of which the main metabolic feature is hypoglicemia and decreased
concentration of free fatty acids and ketones in serum (insulin inhibits
lypolisis and sinthetizes ketonic bodies), presents a major diagnostic and
therapeutic chalenge. The disease is often followed by brain atrophy
contributed by the attacks of hypoglicemia. It is inherited as an autosomally
recessive and autosomally dominant disease. The genetic defects is located on
the short arm of the chromosome 11. The authors report a successfully applied
conservative treatment in a neonate with persistent hyperinsulinemic
hypoglicemia.
nema |
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ISSN: | 0370-8179 2406-0895 |
DOI: | 10.2298/SARH04S1097M |