Trp64Arg polymorphism of the ß₃-adrenergic receptor and its association with obesity in the young population of North Macedonia

The pandemic surge of obesity is becoming a concern for civilization. Genetic factors play an important role in obesity. The polymorphism of the beta3-adrenergic receptor gene (ADRB3), whose protein is located mainly in adipose tissue, has been associated with body weight disorders and obesity. The relationship between the ADRB3 polymorphism and BMI has been controversial. Our research examines the impact of the Trp64Arg polymorphism in the ADRB3 gene on anthropometric and biochemical parameters. Analyzing data from 110 young North Macedonians, we employed PCR-RFLP genotyping alongside biochemical and anthropometric assessments. Obesity was measured using the body mass index (BMI), and weight groups were determined according to World Health Organization (WHO) guidelines. Significant associations emerged between ADRB3 genotypes and crucial biochemical parameters-glucose, triglyceride, and cholesterol levels. P-values of 0.013, 0.011, and 0.025, respectively, indicate a potential correlation between specific genotypes and variations in these metabolic markers. This pioneering study sheds light on ADRB3's role in metabolic health, offering potential for personalized interventions and emphasizing the need for further research in the North Macedonian population.