Gastroprotective effects of novel antidotal combination in rats acutely poisoned by T-2 toxin

The purpose of this experiment was to evaluate the antidotal potencies of methylprednisolone (soluble form, Lemod-solu(R)), nimesulide, N-acetylcysteine (Fluimucil(R)) and their combinations in rats treated with 1.0 LD50 (0.23 mg/kg) of trichothecene mycotoxin, T-2 toxin. Their antidotal efficacy was investigated by monitoring their effects on general condition, 24-hour-survival, body weight gain, food and water consumption and pathohistological changes in the gut of Wistar rats acutely treated with a single injection of T-2 toxin during a 4-week period. The results clearly show that methylprednisolone, a well-known anti-inflammatory and immunosuppressive drug, exerts the best antidotal effect against T-2 toxin intoxication in rats.