Production of H2O2 and NO by rat peritoneal macrophages in response to gut commensal bacteria

The aim of the present study was to compare the levels of hydrogen peroxide (H2O2) and nitric oxide (NO) produced by resident peritoneal macrophages from the autoimmune disease susceptible Dark Agouti (DA) rats vs. resistant Albino Oxford (AO) rat strain, under basal conditions and subsequent to in...

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Veröffentlicht in:	Acta veterinaria (Beograd) 2009, Vol.59 (2-3), p.111-122
Hauptverfasser:	Kovacevic-Jovanovic, V, Mitic, K, Stanojevic, S, Miletic, T., Immunology Research Centre Branislav Jankovic, Belgrade (Serbia). Institute of Virology, Vaccines and Sera Torlak, Vujic, V., University of Belgrade, Belgrade (Serbia). School of Medicine, Institute of Chemistry, Dimitrijevic, M., Immunology Research Centre Branislav Jankovic, Belgrade (Serbia). Institute of Virology, Vaccines and Sera Torlak
Format:	Artikel
Sprache:	eng
Schlagworte:	BACTERIA COMENSALISMO COMMENSALISM COMMENSALISME http://www.fao.org/aos/agrovoc#c_12316 http://www.fao.org/aos/agrovoc#c_33255 http://www.fao.org/aos/agrovoc#c_36996 http://www.fao.org/aos/agrovoc#c_3725 http://www.fao.org/aos/agrovoc#c_6464 http://www.fao.org/aos/agrovoc#c_765 HYDROGEN PEROXIDE MACROFAGOS MACROPHAGE MACROPHAGES NITRIC OXIDE OXIDO NITRICO OXYDE NITRIQUE PEROXIDO DE HIDROGENO PEROXYDE D'HYDROGENE RAT RATA RATS
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Zusammenfassung:	The aim of the present study was to compare the levels of hydrogen peroxide (H2O2) and nitric oxide (NO) produced by resident peritoneal macrophages from the autoimmune disease susceptible Dark Agouti (DA) rats vs. resistant Albino Oxford (AO) rat strain, under basal conditions and subsequent to in vitro stimulation with gut commensals. Our results demonstrated that macrophages from AO rats have higher potential to produce H2O2 and NO in response to specific commensal bacteria when compared to DA rats. A possible relationship between the macrophage activity in response to commensal bacteria and the susceptibility to induction of autoimmune/inflammatory diseases in AO and DA rat strains is suggested.
ISSN:	0567-8315 1820-7448
DOI:	10.2298/AVB0903111K