Transitional Meningioma in a Dog

Background: Dogs and cats are the most common domestic animal species diagnosed with primary neoplasms of the central nervous system. Of these, meningioma is the brain tumor most commonly reported in dogs and is associated with several neurological changes, such as seizures. The ante mortem diagnosis is difficult to make because the use of computerized tomography, the gold standard for the presumptive diagnosis of brain tumors, is still a limited and expensive exam in veterinary medicine. The aim of this study is to report the case of a grade II transitional meningioma in a female dog attended and necropsied at the Veterinary Hospital of the Universidade Estadual de Santa Cruz (HV-UESC).Case: A 13-year-old female poodle was examined at HV-UESC with a clinical history of prostration, apathy, anorexia, partial vision loss, and neurological abnormalities, including seizures. The dog was being treated with phenobarbital (2 mg/kg three times a day) for seizures and doxycycline (5 mg/kg twice a day) for anaplasmosis diagnosed prior to clinical care at HV-UESC. On physical examination, the dog was observed to be mentally altered, with increased aggression, walking in large circles to the left, tremors and spasticity of the thoracic limbs. Laboratory analysis revealed a normal complete blood count. Biochemical analysis revealed an increase in alanine aminotransferase (296 U/mL), alkaline phosphatase (286 U/mL) and urea (121 mg/dL) levels. Based on the clinical and laboratory abnormalities, the suspicion of cerebral degenerative neuropathy or neoplasia was established. The dog was examined again approximately two months after initial presentation and no improvement in the dog’s neurological condition was noted; in fact, the dog´s condition had deteriorated, which was evidenced by worsening seizures, tetraparesis and bedsores. Due to the severity of the neurological changes, euthanasia was performed. After authorization from the owner, the dog was referred to the HV-UESC Necropsy Department, where the dog was necropsied. The primary macroscopic finding was a well-defined mass measuring approximately 2.5x1.5x1.5 cm in the frontal cortex of the left cerebral hemisphere. The lesion was firm and white with an irregular surface and was adhered to the dura mater. The mass compressed the adjacent brain tissue. Histopathological analysis demonstrated a non-encapsuled, expansive, and partially delimited neoplasm characterized by sheets of meningoendothelial cells arranged pr