PHYTOCHEMISTRY AND ANTIMICROBIAL ACTIVITY OF METHANOLIC STEM EXTRACT OF BOMBAX BUONOPOZENSE P.BEAUV (SILK COTTON TREE)

Background: The aim and objective of this study was to evaluate methanolic extract of Bombax buonopozense (stem) for antimicrobial and phytochemical screening. Methods: The methanolic stem extract of B. buonopozense with documented ethno-medicinal applications were fractionated in different solvents (n-hexane, chloroform, ethyl acetate, n-butanol and water) and subjected to phytochemical screening and antimicrobial activity against some disease-causing microorganisms including gram positive and gram negative (Staphylococcus aureus, Salmonella spp and Escherichia coli). The antimicrobial tests were carried out in triplicates, the data obtained were subjected to one-way ANOVA using statistical package for social science (SPSS). Results: Phytochemical screening revealed the presence of Alkaloids, saponins, saponin glycosides, Tannins, hydrolysable Tannins, steroids and triterpenoids, flavonoids, phenols and volatile oils. Each fractions of the extract demonstrated antibacterial activity against all the organisms tested. MIC values of each fractions revealed strong inhibition against all the organisms tested. The methanolic stem extract of B. buonopozense in chloroform, water, ethyl acetate, n-hexane and n-butanol showed the following MIC values. S. aureus. 6.25, 25, 12.5, 6.25, and 12.5. E. coli 100, 100, 50, 6.25 and 12.5. Salmonella spp. 3.125, 12.5, 25, 3.125 and 12.5 respectively. Conclusion: This study shows that the extract posses’ antimicrobial properties which can be used as alternatives to conventional antibiotics. Peer Review History: Received: 25 August 2022; Revised: 8 October; Accepted: 8 November, Available online: 15 November 2022 Academic Editor: Dr. Jennifer Audu-Peter, University of Jos, Nigeria, drambia44@gmail.com Received file: Reviewer's Comments: Average Peer review marks at initial stage: 5.0/10 Average Peer review marks at publication stage: 7.0/10 Reviewers: Dr. Sangeetha Arullappan, Universiti Tunku Abdul Rahman, Malaysia, sangeetha@utar.edu.my Prof. Ali Gamal Ahmed Al-kaf, Sana'a university, Yemen, alialkaf21@gmail.com Similar Articles: IN -VIVO ANTI-DIARRHOEAL ACTIVITY OF METHANOL EXTRACT OF BOMBAX BUONOPOZENSE CRITICAL REVIEW ON BOMBAX CEIBA, ALOE VERA AND XIMENIA AMERICANA