Preformulation Studies of Intranasal Solid Lipid Nanoparticles of Mometasone Furoate

The objective of the present work was to prepare intranasal solid lipid nanoparticles (SLN) of mometasone furoate. Mometasone furoate is BCS class II drug having low aqueous solubility and highly sensitive to hepatic metabolism. Mometasone furoate loaded nanoparticles were prepared by high pressure homogenization technique. The preformulation studied was conducted by studying various selection criteria. Lipid was chosen on the basis of maximum solubility of the drug in lipid. Glyceryl monostearate was selected as the lipid phase which showed maximum drug solubility than other lipids. Selection of surfactant, homogenization pressure and no. of homogenization cycle was done on the basis of minimum particle size and maximum % entrapment efficiency. These results showed high entrapment efficiency and minimum particle size. Keywords: Intranasal solid lipid nanoparticles, High pressure homogenization, Glyceryl monostearate.