Chemoprotective Effect of Carwin Capsules against Cyclophosphamide Induced Genotoxicity by In Vivo Micronucleus Assay

The protective effects of carwin capsules (CAR) against toxicity induced by cyclophosphamide (CYC) in mice were investigated using the micronucleus assay for anticlastogenic activity in mouse bone marrow cells. The experimental animals were pre-treated orally with the drug suspension (carwin capsule suspension) for seven consecutive days (drug alone in group III and in combination with standard drug in group IV). The standard drug (cyclophosphamide, 50 mg/kg bw) was dissolved in saline and injected intraperitoneally. The results demonstrate that carwin was found to be significant (P