EFFERVESCENT TABLET FORMULATION ETHANOL EXTRACTS 70% KELAKAI ROOT (STENOCHLAENA PALUTRIS (BURM. F.) BEDD.) WITH VARIATION CONCENTRATION OF GAS GENERATING AGENT

Objective: The aim of this study is to determine the optimal formula of effervescent tablets 70% ethanol extract of Kelakai root (Stenochlaena palutris (Burm. f.) Bedd.) with variations concentration in gas generating agents and their effects on properties of the physical effervescent tablet. Methods: Kelakai root was extracted with maceration using ethanol 70%, and total phenolic-flavonoids contents were determined. Effervescent tablets made for three formulas base on varying concentration gas generating agents. Effervescent tablets made by wet granulation. Evaluation physical properties of granules included flowability, tapped density, bulk density, and angle of repose. Evaluation physical properties of effervescent tablets included weight uniformity, thickness and diameter, friability, pH, hardness, effervescent time, and hedonic test. Results: The extract had a total phenolic content of 625.35 μg GAE/mg extract, while the total flavonoid content was 735.24 μg QE/mg extract. The effervescent tablets have uniformity of sizes ranging from 1.29 to 1.3 cm and thickness from 0.49 to 0.5 cm, uniformity of weights with a coefficient of variation ranging from 1.04%-2.15%, fragility ranged from 0.03%-0.29%, tablet hardness ranged from 8.33-9 kg, and solubility ranged from 30-86 min. Statistical analysis showed that the p-value is>0.05, which means there are no significant differences between formulas by varying concentrations of citric acid and tartaric acid to influence the physical characteristics of effervescent tablets. Conclusion: Formula III was the best formula because it meets the physical requirements and hedonice test of granules and tablets.