ATHEROPROTECTIVE EFFECT OF SOLANUM BETACEUM ON RAT EXPOSED TO CIGARETTE SMOKE

Objective: The objective of this research was to determine the atheroprotective effect of Solanum betaceum ethanol extract toward carotid arteryintima-media thickness (cIMT) and the level of malondialdehyde (MDA) on rats exposed to cigarette smoke.Methods: Thirty adult Rattus norvegicus strain Wistar were divided into five groups and exposed to cigarette smoke, 3 pc cigarette/day andsimultaneously administered with S. betaceum in Group K2, K3, and K4 (100 mg/kg b.w/day; 200 mg/kg b.w/day; and 400 mg/kg b.w/day),respectively. The duration of treatment for all groups was 28 days. Blood was withdrawn from the cardiac to determine the MDA level. Histologicalslide from carotid artery intima-media was collected to determine cIMT.Results: S. betaceum ethanol extract administration could significantly prevent the development of atherosclerosis due to oxidative stress bydecreasing the level of MDA (p