EFFECT OF AQUEOUS EXTRACT OF CYNODON DACTYLON (DOOB GRASS) ON NORMAL AND IMPAIRED MEMORY IN MICE

Objective: Memory impairment in any age affects the quality of life, though this problem is common in old age. The present study was carried out to study the effect of aqueous extract of Cynodon dactylon (AECD) on normal and impaired memory in mice. Methods: The gum acacia suspension of AECD was adm...

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Veröffentlicht in:Asian journal of pharmaceutical and clinical research 2022-09, p.130-133
Hauptverfasser: KOTHARI, SAROJ, SAHU, MONIKA
Format: Artikel
Sprache:eng
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Zusammenfassung:Objective: Memory impairment in any age affects the quality of life, though this problem is common in old age. The present study was carried out to study the effect of aqueous extract of Cynodon dactylon (AECD) on normal and impaired memory in mice. Methods: The gum acacia suspension of AECD was administered by gavage at the dose of 200 and 400 mg/kg for 30 days to evaluate memory-enhancing effect on normal and scopolamine-induced impaired memory in albino mice. Escape latency (EL) in Morris water maze (MWM) and transfer latency (TL) in elevated plus maze were recorded. Mice were given four trial sessions per day to locate the platform for 5 days in MWM model. Scopolamine 1 mg/kg was injected i.p. to produce memory impairment in mice. Results: AECD at the dose of 200 mg/kg (p>0.05) and 400 mg/kg (p0.05) and 400 mg/kg (p
ISSN:0974-2441
0974-2441
DOI:10.22159/ajpcr.2022.v15i9.45109