THE OUTCOME OF CEFUROXIME VERSUS METRONIDAZOLE AS SURGICAL PROPHYLAXIS FOR HYSTERECTOMY - A RETROSPECTIVE STUDY IN A SOUTH INDIAN SETUP

ABSTRACTObjective: To evaluate the outcome of cefuroxime and metronidazole as surgical prophylactic measure for hysterectomy procedures in a South Indiansetup.Methods: A retrospective study was conducted in 60 women who underwent hysterectomy and was prescribed metronidazole and cefuroxime. Thedata regarding demographic details, presenting complaints, parity, obstetrics history, diagnosis, and need for hysterectomy were evaluated.Results: A total of 148 women admitted with hysterectomies performed were taken into consideration of which 68 were prescribed cefuroxime andmetronidazole alone but 8 patients did not respond to treatment and were given other antibiotics, hence 60 patients formed the study population. Themean age was 20±05.29 years. Patients above 51 years were mostly seen. Uterovaginal prolapse was very commonly observed, anemia (mild=7) wasthe main risk factor found, cefuroxime was commonly prescribed compared to metronidazole, and febrile episodes were commonly noticed. One-wayANOVA revealed the F ratio to be 6.04, p value calculated as 0.06 significant at p≤0.10.Conclusion: In our study, cefuroxime appeared to be effective in prophylaxis against infections. Metronidazole appeared to be ineffective comparedto cefuroxime.Keywords: Antibiotic, Surgical prophylaxis, Hysterectomy, Infections.