EFFECT OF PHARMACOLOGICAL DOSES OF GARLIC AND OMEGA 3 ON GASTRIC LESIONS INDUCED BY ETHANOL IN MICE

ABSTRACTObjective: This work was designed to investigate and compare the possible protective effect of pharmacological doses of garlic and omega 3 againstgastric lesions induced by ethanol in mice.Methods: A total of 30 mice involved in the study were divided into five groups with 6 mice for each. G...

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Veröffentlicht in:Asian journal of pharmaceutical and clinical research 2016-09, Vol.9 (5), p.153
1. Verfasser: Jaccob, Ausama Ayoob
Format: Artikel
Sprache:eng
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Zusammenfassung:ABSTRACTObjective: This work was designed to investigate and compare the possible protective effect of pharmacological doses of garlic and omega 3 againstgastric lesions induced by ethanol in mice.Methods: A total of 30 mice involved in the study were divided into five groups with 6 mice for each. Groups 1 (ulcer control) and 2 (normal control),Groups 3 (positive ulcer control treated with ranitidine 50 mg/kg), Groups 4 and 5 treated with garlic oil and omega 3 oil at doses 200 and 150 mg/kg,respectively. All groups treated orally by gastric gavage once daily for 14 days before starting gastric ulcer (GU) induction process by absolute ethanoladministration.Results: A treatment with garlic and omega 3 ameliorated the severity of gastric ulceration evidenced by reduced ulcer index area, increase %gastroprotection, increase mucus content, reduced erosions, and necrosis.Conclusion: Oral administration of pharmacological doses of garlic oil and omega 3 oil shows significant gastroprotection against GU models inducedby absolute ethanol confirmed by biochemical and histological data.Keywords: Gastric ulcer, Garlic, Omega 3, Gastroprotection.
ISSN:0974-2441
0974-2441
DOI:10.22159/ajpcr.2016.v9i5.12833