Karakteristik Toksisitas Hidroksiapatit yang Disintesis dari Kalsit Terhadap Rattus norvegicus

The use of synthetic hydroxyapatite (HA) in biomedical application is well warranted. It has shown to havean excellent biocompatibility in human tooth and bones. The present study was conducted to know the toxicitycharacteristics of hydroxyapatite synthesized from Mojokerto calcite in Rattus norvegicus. In this study 30Rattus norvegicus were used as experimental animals. The animals were divided into 3 groups (n=10) to be givenHA-calcite, HA-200 (Waco, Japan), and aquadest (control) orally. The animals were observed 7 days and thenwere analyzed for: fatality rate and clinical behavior, hematology test, organ morphology, and histopathologyappearance. The result showed that there was not any animal death during 7 days observation. None of the animalexhibited any noteworthy findings in clinical behavior, hematology test, organ morphology, and histopathologyappearance. In conclusion, HA-calcite did not show any acute toxicity characteristic; therefore, it was potential tobe used as an alternative material for bone substitution.