The Effects of Hemodilution and Controlled Hypotension on Liver Function and Renal Tubular Function

Controlled hypotension by prostaglandin E1 (PGE1) under hemodilution of hematocrit (Hct) 23% was performed during hip surgery, and liver function and renal tubular function were compared with those in the case of hemodilution of Hct 31% by measuring arterial blood ketone body ratio (AKBR) and urine N-acetyl-β-D-glucosaminidase (NAG-index), respectively. No marked change was observed in the AKBR values after hemodilution, during hypotension and post-operation compared to the control values (before hemodilution) and also those of the group with Hct 31%. NAG-index values significantly increased in the hemodilution Hct 23% group after hypotension and post-operation compared with either the control or Hct 31% group. No marked change was noted in liver or kidney functions by blood examinations for one month after the operation. These results indicate that liver function is maintained normally under the controlled hypotension induced by PGE1 with hemodilution of Hct 23%. However, renal tubular function is temporarily affected, while clinical manifestation and other abnormal clinical findings in renal function are not observed throughout.