Treatment Strategies for Antibody-mediated Rejection in Kidney Transplantation and Its Prevention

This article reviews the current treatment strategies of antibody-mediated rejection in kidney transplantation, which is increasingly recognized as the leading immunological cause of graft failure. The pathophysiologic complexity of this condition poses significant challenges for its treatment; howe...

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Veröffentlicht in:OBM Transplantation 2020-09, Vol.4 (3), p.1-16
Hauptverfasser: Di Cocco, Pierpaolo, Fratti, Alberto, Kaylan, Kerim, Tzvetanov, Ivo G, Benedetti, Enrico
Format: Artikel
Sprache:eng
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Zusammenfassung:This article reviews the current treatment strategies of antibody-mediated rejection in kidney transplantation, which is increasingly recognized as the leading immunological cause of graft failure. The pathophysiologic complexity of this condition poses significant challenges for its treatment; however, progress toward advancing our understanding of its pathogenesis and diagnosis will allow for identification of new therapeutic targets. Emphasis is also given to prevention, which is mainly based on careful assessment of the transplant candidate and immunological risk stratification.
ISSN:2577-5820
2577-5820
DOI:10.21926/obm.transplant.2003119