A Simple Way to Identify Functional Sites in Protein: III. Application of DEV Analysis to Proteins Other than Trypsin

Applicability of the DEV analysis is investigated to various proteins other than trypsin. The strategies A and B are mainly employed to identify possible functional sites of protein. The strategies C and D help to improve assignment of a functional system, and a higher-dimensional model constructed by the DEV analysis gives an essential knowledge of functional sites of protein. Some functional sites were found to locate near active sites that are already known experimentally, and the other have proved of another function. The DEV analysis, based on a simple logic, has rather mathematical nature as well as topological concept.