Immunochemical Studies on Human Cancer. II: Detection of a Urinary Antigenic Substance Common to Gastric Cancer Tissue

Antibody reacting with urine from cancer patients was produced in rabbits immunized with urine from gastric cancer patients. Specimens of intact urine from the cancer patients revealed a direct precipitation reaction with the specific antiserum by the agar gel diffusion technique. The reaction of the specific antiserum with urine from cancer patients was inhibited by most concentrated urine specimens from the cancer patients. The reaction was also inhibited by D-glucosamine hydrochloride and D-galactosamine hydrochloride, i.e., by the same sugars as in the case of the reaction of anti-gastric cancer immune serum.