A clinical study on lupus anticoagulant in systemic lupus erythematosus

A clinical study on lupus anticoagulant in systemic lupus erythematosus

Seventy Japanese patients with systemic lupus erythematosus (SLE) were studied to define clinical and laboratory characteristics of lupus anticoagulant (LA). To detect LA activity, a mixing test of APTT was performed according to the method of Colaco et al., using the 1:5 diluted phospholipid reagen...

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Veröffentlicht in:Japanese Journal of Clinical Immunology 1987/02/28, Vol.10(1), pp.78-84
Hauptverfasser: Mayumi, Takehito, Nagasawa, Kohei, Yamauchi, Yasuo, Naito, Yasushi, Kusaba, Tomohiro, Niho, Yoshiyuki, Kimura, Junichiro
Format: Artikel
Sprache:eng
Schlagworte:
cerebral infarction
lupus anticoagulant
spontaneous abortion
systemic lupus erythematosus
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Zusammenfassung:Seventy Japanese patients with systemic lupus erythematosus (SLE) were studied to define clinical and laboratory characteristics of lupus anticoagulant (LA). To detect LA activity, a mixing test of APTT was performed according to the method of Colaco et al., using the 1:5 diluted phospholipid reagent. As a result, LA was found in the plasma of 11 of 70 patients (16%) with SLE. The incidence of spontaneous abortion in LA-positive and LA-negative women were 7 of 18 pregnancies (39%) and 7 of 73 pregnancies (10%), respectively. The difference was highly significant (p
ISSN:0911-4300
1349-7413
DOI:10.2177/jsci.10.78