A Fatal Case of Fulminant Myocarditis with Human Herpesvirus-6 Infection

We report a case of fulminant myocarditis after steroid pulse therapy for acute hepatitis. Serological studies demonstrated a four-fold increase in the antibodies against human herpesvirus-6 (HHV-6) IgG, and a PCR showed the existence of HHV-6 virus DNA. HHV-6 virus DNA was also isolated from the li...

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Veröffentlicht in:	Internal Medicine 2000, Vol.39(8), pp.632-636
Hauptverfasser:	FUKAE, Satoki, ASHIZAWA, Naoto, MORIKAWA, Suguru, YANO, Katsusuke
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Viral - blood Biological and medical sciences DNA, Viral - genetics DNA, Viral - isolation & purification Drug toxicity and drugs side effects treatment Fatal Outcome hepatitis Hepatitis - drug therapy Herpesviridae Infections - etiology Herpesviridae Infections - immunology Herpesviridae Infections - virology Herpesvirus 6, Human - genetics Herpesvirus 6, Human - isolation & purification Herpesvirus 6, Human - pathogenicity Humans Male Medical sciences Methylprednisolone - adverse effects Middle Aged Myocarditis - etiology Myocarditis - immunology Myocarditis - virology Pharmacology. Drug treatments polymerase chain reaction (PCR) steroid pulse therapy Toxicity: cardiovascular system
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Zusammenfassung:	We report a case of fulminant myocarditis after steroid pulse therapy for acute hepatitis. Serological studies demonstrated a four-fold increase in the antibodies against human herpesvirus-6 (HHV-6) IgG, and a PCR showed the existence of HHV-6 virus DNA. HHV-6 virus DNA was also isolated from the liver and the heart. We believe that exacerbation of fulminant myocarditis was probably associated with the reactivation of HHV-6 due to the immunosuppressive state of the host. (Internal Medicine 39: 632-636, 2000)
ISSN:	0918-2918 1349-7235
DOI:	10.2169/internalmedicine.39.632