HEMODYNAMIC CHANGES IN LOW DOSE INTRATHECAL DEXMEDETOMIDINE AND CLONIDINE AS ADJUVANT TO BUPIVACAINE - A COMPARATIVE STUDY

Background : To evaluate the effect of low dose intrathecal dexmedetomidine and clonidine as adjuvant to bupivacaine on hemodynamic parameters of the patients . A total of 60 patients , scheduled for lower abdominal , lower limb and gynaecological procedures were selected to participate in this prospective , randomised double blind study . After injecting the drug time were noted (T0) and the patient were turned to supine position . Preoperative systolic and diastolic blood pressure , Heart rate were noted at specific time interval. Results : Heart rate , systolic blood pressure , diastolic blood pressure and mean arterial pressure were compared in both the groups and there was no statistically significant difference between the two groups . Conclusions : Both clonidine and dexmedetomidine as adjuvant to bupivacaine showed fall in heart rate , systolic blood pressure , diastolic blood pressure and mean arterial blood pressure . However there was no statistically significant difference between the two groups in these parameters.