CYP3A4 Gene Polymorphisms Influence Testosterone 6β-hydroxylation

CYP3A4 Gene Polymorphisms Influence Testosterone 6β-hydroxylation

Three non-synonymous single nucleotide polymorphisms (SNPs) in the CYP3A4 gene were found in 34 cell lines derived from Japanese individuals. These three SNPs (T185S, L293P, and T363M)1 have been previously reported, but little is known about the effect that these polymorphisms, especially T185S, ha...

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Veröffentlicht in:Drug metabolism and pharmacokinetics 2002, Vol.17 (2), p.150-156
Hauptverfasser: Murayama, Norie, Nakamura, Takahiro, Saeki, Mayumi, Soyama, Akiko, Saito, Yoshiro, Sai, Kimie, Ishida, Seiichi, Nakajima, Osamu, Itoda, Masaya, Ohno, Yasuo, Ozawa, Shogo, Sawada, Jun-ichi
Format: Artikel
Sprache:eng
Schlagworte:
amino acid substitution
CYP3A4
metabolism
single nucleotide polymorphism (SNP)
testosterone 6β-hydroxylation
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Zusammenfassung:Three non-synonymous single nucleotide polymorphisms (SNPs) in the CYP3A4 gene were found in 34 cell lines derived from Japanese individuals. These three SNPs (T185S, L293P, and T363M)1 have been previously reported, but little is known about the effect that these polymorphisms, especially T185S, have on catalytic activity. We measured testosterone hydroxylation in wild-type CYP3A4 and these three variants using a mammalian expression system. Testosterone 6β-, 2β-, and 15β-hydroxylations by the variant CYP3A4 forms T363M (
ISSN:1347-4367
1880-0920
DOI:10.2133/dmpk.17.150