Identification of transcription factors activated by methylmercury in mouse brain

Identification of transcription factors activated by methylmercury in mouse brain

Methylmercury is a harmful heavy metal that selectively disrupts the central nervous system. To clarify the transcription induction mechanism that operates in the brain in response to methylmercury exposure, we used a protein/DNA binding assay to identify transcription factors activated in the cereb...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Fundamental Toxicological Sciences 2017/02/24, Vol.4(1), pp.37-39
Hauptverfasser: Kim, Min-Soek, Takahashi, Tsutomu, Lee, Jin-Yong, Miura, Nobuhiko, Asanuma, Masato, Hwang, Gi-Wook, Naganuma, Akira
Format: Artikel
Sprache:eng
Schlagworte:
Brain
Methylmercury
Transcription factor
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Methylmercury is a harmful heavy metal that selectively disrupts the central nervous system. To clarify the transcription induction mechanism that operates in the brain in response to methylmercury exposure, we used a protein/DNA binding assay to identify transcription factors activated in the cerebella of mice administered methylmercury. We identified PAX4, PAX6, TCF3 and HMGA1 as transcription factors activated by methylmercury.
ISSN:2189-115X
2189-115X
DOI:10.2131/fts.4.37