DIURETIC, ANTIDIURETIC AND LAXATIVE ACTIVITIES OF ANTHOCLEISTA VOGELII EXTRACTS IN RATS

Background: Anthocleista vogelii Planch is a medicinal plant used by traditional healers in the treatment of Malaria, hypertension, ulcer, obesity, diabetes, and as a diuretic and purgative in Africa. Therefore, the present study sought to evaluate the diuretic, antidiuretic and laxative activities of the root bark of A. vogelii extracts and fractions in male Sprague-Dawley rats. Materials and methods: Sixty rats were placed in 10 groups which included: control (normal saline), furosemide/sodium picosulfate (25 mg/kg) as standard drugs, methanol extracts (250 mg/kg and 500 mg/kg), and 125 mg/kg and 250 mg/kg of saponin, flavonoid and neutral alkaloid fractions of A. vogelii. The drugs/extracts/fractions were administered orally using normal saline as the vehicle. Results: The 500 mg/kg methanol extracts (ME) significantly increased (p