Electrochemical Determination of Vitamin A Based on a Novel Nanoalloy Modified Carbon Paste Electrode

Preeclampsia has been proposed to occur after a partial breakdown in tolerance during fetal development due to maternal immune maladaptation. A few of the immunomodulatory features of the hormonal vitamin A system have the potential for enhancing immunity during pregnancy. This study proposed a new carbon paste electrode (CPE) that was modified using a nanoalloy (Pt:Co) room-temperature ionic liquid (RTIL) as an extremely sensitive sensor for the voltammetric detection of vitamin A in food specimens. The proposed sensor was found to be effective for vitamin A electro-oxidation in aqueous solutions. As an extremely sensitive electrochemical technique, square-wave voltammetry (SWV) was used for the detection of vitamin A (in submicromolar amounts). The linear response range and detection limit were found to be 0.1 μM to 100 μM and 0.04 μM, respectively. The developed sensor can be used for the detection of vitamin A in tablet and food specimens.