On-chip Hematocrit Correction for Whole Blood Glucose Amperometric Sensing Strip Using a Post-Measurement Potential Step

The accuracy of a point-of-care whole blood glucose sensor can be considerably influenced by hematocrit; therefore, an on-chip Hct correction protocol was developed and incorporated to meet the clinical demands. An impulse of DC 0.3 V was first applied for detecting blood glucose amperometrically, f...

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Veröffentlicht in:International journal of electrochemical science 2017-06, Vol.12 (6), p.4990-4999
Hauptverfasser: Weng, Chih-Wei, Cheng, Tzong-Jih, Chen, Richie L.C., Hsieh, Bo-Chuan
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Sprache:eng
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Zusammenfassung:The accuracy of a point-of-care whole blood glucose sensor can be considerably influenced by hematocrit; therefore, an on-chip Hct correction protocol was developed and incorporated to meet the clinical demands. An impulse of DC 0.3 V was first applied for detecting blood glucose amperometrically, followed by an additional 3.2 V DC impulse for Hct estimation. Without Hct correction, the results of blood glucose tests were negatively correlated with Hct levels, and the glucose values were overestimated by 38.8% and underestimated by 43.8% when the Hct levels were 9% and 70%, respectively. On the other hand, all the mean biases of blood glucose tests with 5 designed Hct levels (9%, 25%, 43%, 55% and 70%) were less than ±10% by utilizing the proposed Hct correction method. The method was insensitive to several representative interfering chemicals.
ISSN:1452-3981
1452-3981
DOI:10.20964/2017.06.87